Title : Development of versatile nanocarrier platforms in nanomedicine and food preservation
Nanotechnology is a versatile technology which has allowed new advances in medical, agriculture and pharmaceutical areas through the nanomaterials designing and modulation. The presentation will focus on the chemical modification of chitosan polymer in order to demonstrate their versatile use as a hydrophobic drug delivery system with potential using in anti-inflammatory treatment, and as a nanomaterial to forming nanocomposite for food preservation.
Chitosan nanoparticles can be formed by electrostatic interaction with polyanions and self-assembled by amphiphilic properties, however, the final properties like charge density and particle size are important in biological response. Our work showed how the modification degree of chitosan polymer affected the encapsulation of anti-inflammatory drug, the cell interaction with a macrophage cell line and their anti-inflammatory action. Chitosan was modified with an acid fat in different ratios, and the modification degree allowed to get particle size between 400-300 nm and zeta potential values between 32-42 mV. Nanoparticles with zeta potential close to 42 mV showed an increasing of inflammatory response in the cell line, while nanoparticles with density charged close to 32 mV showed a cell interaction favourable and the inflammatory response decreased.
On the other hand, news materials have been developed to extend the post?harvest shelf life of climacteric fruits. The influence of chitosan amphiphilic nanoparticles encapsulating an essential oil (NpsChO) were evaluated in starch nanocomposites. Starch polymer was modified chemically with poly (ethylene glycol) methyl ether and the nanoparticles were incorporated in the polymer solution in order to get the nanocomposites coatings. The chitosan nanoparticles were using as antimicrobial agent and their effect on thermal properties of the nanocomposite’s coatings based on starch-NpsChO were evaluated.
So, we will show how the same chitosan nanoparticles system can be using in different applications and the importance of physicochemical properties modulation.
Audience take away:
• Audience will learn about the advantages of the chemical modifications of natural polymers in the designing of nanocarriers for the different applications.
• Audience will learn about the versatile applications of chitosan nanoparticles as drug delivery system and nanocomposite for food preservation.
• The approaches demonstrated in the presentation will provide new information to expand knowledge for research and teaching.