2nd Edition of World Nanotechnology Conference

April 19-21, 2021 | Virtual Event

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April 19-21, 2021 | Virtual Event

Mirza Muhammad Faran Ashraf Baig

Speaker for Nanotechnology Conferences 2020
Mirza Muhammad Faran Ashraf Baig
Nanjing Universitym, China
Title : DNA scaffold nanoparticles coated with HPMC/EC for oral delivery


The control of the glycemic level among diabetes type 2 patients is very important for their long term survival and avoiding further complexities including micro/macrovascular diseases as well as diabetic neuropathy. Vildagliptin (VD) is a drug that has addressed these issues successfully with the desired safety portfolio. 
Methods: We used DNA-nanocubes for initial nano-encapsulation of VD followed by HPMC/EC coating. 
Results: The results revealed the stable, smooth, spherical and nano-sized nanoparticles with improved size uniformity (from 100 to 400 nm in diameter) and encapsulation-efficiency (E.E.%) than previously reported (500–2000 nm) with the chemical compatibility evident in ATR/FTIR and DSC results. Animal experiments results revealed the improvement of incretin level in the serums due to potent DPP-4 inhibition compared to the free-VD/solution with better maintenance of glycemic levels after feeding. The safety of these HPMC/EC-DNA-VD nanoparticles was assessed through the histological-examination after completion of the treatment turn. The solvent evaporation technique provided the better coating of HPMC around DNA-core with gastro-resistant and effervescent property due to presence of NaHCO3 (0.01%) in the formulations that caused delayed delivery of VD as well as nanoparticles to the intestine, increasing the availability time of the drug and nanospheres at the target sites (intestine and blood) where DPP-4 enzyme is most abundant (to degrade the GLP-1 and GIP causing loss of control of the postprandial glycemic levels. 
Conclusion: So the availability of sustained release nanospheres near the target sites and prolonged DPP-4 inhibition improved the outcomes of the therapy.


Dr. Mirza Muhammad Faran Ashraf Baig (Ph.D.) is a research scholar at Nanjing University, China and a Lecturer at Multan Medical and Dental College, Multan, Pakistan. He currently works in the State Key Laboratory of Analytical Chemistry for Life Sciences and cooperates with the State Key Laboratory of Pharmaceutical Biotechnology of Nanjing University. The field of research is the application of DNA nanotechnology in drug delivery for cardiovascular diseases, diabetes, oncology and neurology. His many papers have been published in the famous SCI magazines, such as Nano Letters (USA), Nanoscale (UK), International Journal of Pharmaceutics (USA), Biomedicine & Pharmacotherapy (USA), Journal of Drug Delivery Science and Technology (France), Journal of Food and Drug Analysis (Taiwan), Journal of Nanoparticles Research (Netherlands), and Applied Nanoscience (Switzerland).