Title : Improved cisplatin-based antitumor drug delivery using a graphene oxide nanoplatform
Abstract:
Cancer is a major cause of death globally and is caused by a variety of factors, including genetics, physical and chemical exposure, and lifestyle habits such as poor diet or smoking. It has been extensively studied in terms of epidemiology and mechanisms, and the main treatment strategies include surgery, chemotherapy, radiotherapy, and newer approaches such as immune and gene therapies. After surgery, chemotherapy is the most commonly used treatment, as it targets the high proliferation rate of cancer cells by interfering with their metabolism. Platinum-based drugs are commonly used in chemotherapy to treat cancer, but their effectiveness is limited by degradation, toxicity, and drug resistance. The nanoplatform enhances cellular accumulation of the drug in target cells and reduces toxicity in normal cells.
The study aims to develop a graphene oxide-based 2D nanoplatform functionalized with highly branched, eight-arm polyethylene-glycol, to deliver platinum-based chemotherapy drugs (Pt) for cancer treatment. The results show that the nanoplatform allows for the use of lower amounts of the drug while achieving similar effects and demonstrates promising results in inhibiting cellular proliferation, migration, and the metastatic process in different types of cancer, such as osteosarcoma, glioblastoma, and breast carcinoma. The nanoplatform can be tailored to target different cancers.
Results show that the nanoplatform [email protected] can use lower amounts of the platinum drug while still achieving similar effects as Pt-free complex. The nanoplatform [email protected] also shows promising results in inhibiting cellular proliferation in osteosarcoma (MG63, U2-OS and SAOS-2 cell lines) and glioblastoma (U87 and U118 cell lines), and inhibiting migration in highly invasive breast carcinoma (i.e., MDA-MB-231 cell line). The nanoplatform [email protected] represents a promising tool in cancer treatment that can be tailored to target different cancers.
Audience Take Away:
- Study shows the effect of PEGylation for drug loading.
- Branched 8-arm PEG was used for PEGylation, which brings many advantages compared to linear types of this polymer.
- This in vitro study provides insights into the nanoplatform [email protected] tested on seven different types of tumor lines.
