The deployment of advanced therapeutic options is urgent required in this current pandemic caused by novel coronavirus disease 2019 (COVID-19). The role of nanotechnology could play a vital role to counter this “virus” nano enemy. Nanotechnology has previously been used in developing antiviral and other biological therapeutics successfully. This technique could be used to develop novel antiviral drug as well as vaccine and other health care applications against this coronavirus. This strategy directs the safe and effective delivery of therapeutic options utilizing engineered nanocarriers, blocking interactions of viral protein with host cell and disruption of virus. A number of pre-clinical studies on metallic and liposomal nanoparticles targeting different virus including HIV, Hepatitis, H1N1, Zika, coronavirus are currently in progress.