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4th Edition of World Nanotechnology Conference

April 25-27, 2022

April 25 -27, 2022 | Las Vegas, USA
2022 Speakers

Functionality of Receptor Targeted Zinc-Insulin Quantum Clusters in skin tissue augmentation and bioimaging

Pawandeep Kaur, Speaker at
Thapar Institute of Engineering and Technology, India
Title : Functionality of Receptor Targeted Zinc-Insulin Quantum Clusters in skin tissue augmentation and bioimaging

Abstract:

Quantum clusters with target specificity are suitable for tissue-specific imaging. In the present work, amorphous zinc insulin quantum clusters (IZnQCs) had been synthesized to promote and monitor wound recovery. Easy synthesis, biocompatibility, stability, enhanced quantum yield, and solubility made the cluster suitable for preclinical/clinical exploration. Zn2+ is known for its binding to insulin hexamer. Here we report the reformation of the structure in a quantum cluster form in the presence of Zn2+. The formation of IZnQCs was confirmed by the change in zeta potential from -25.6 mV to -17.9 mV and also the formation of protein metal interaction was confirmed in FTIR bands at 450, 480, and 613 cm-1 for Zn-O, Zn-N, and Zn-S respectively. HRTEM-EDS and SAED data analysis showed an amorphous nature of the cluster. The binding of IZnQCs to the cells has been confirmed using confocal microscopy. IZnQCs showed a synergistic effect in wound recovery than insulin or Zn2+ alone. Further due to high fluorescence this recovery process can be monitored under an appropriate setup. Wound healing promotional activity, target specificity, and fluorescence properties make the IZnQCs ideal to use for bioimaging along with promoting and monitoring of wound recovery agent.

Biography:

Dr. Pawandeep Kaur, DST Inspire Research Fellow, received Ph.D. degree from Thapar Institute of Engineering and Technology, Patiala, Punjab, India. She has published 7 research articles in SCI journals and others are communicated. The research interest is on synthesis of drug loaded nanoformulations for normal and diabetic wound recovery. All over the world, four hundred twenty two million people have diabetes due to excess free body glucose in fluids which lead to various problems including retinopathy, neuropathy, arthritis, damage blood vessels etc.

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