Title : Pivotal involvement of CD-36 mediated VAV protein acts like a catalyst in the interplay between the macrophages and graphene nanoplatelets
CD-36 is known to play a key role in mediating the interaction between the macrophages and graphene nanoplatelets. Graphene nanoplatelets are arranged in the stacks of graphene in a planarly in a two-dimensional manner with an average length and thickness in the microns. The VAV is known to be a key regulator allowing the CD-36 to form the foam cells due to excessive lipid content in the macrophages. The CD-36 molecules are also known to increase the lipidity of the cells thus making the macrophages competent in the cellular metabolism. It has been found that the higher levels of CD-36 are known to accelerate the interaction between the macrophages and graphene nanoplatelets. So, what might be possible molecule behind this? Is the VAV is main agent behind the activity of the CD-36? As the VAV works in the coordination with Ca2+ molecules for the better function of the CD-36, so it might be possible that modifications in the VAV protein with the aid of the CRISPR Cas-9 proteins can lead to inhibited activity of the CD-36 protein that will supress the interaction between the graphene nanoplatelets and macrophages. This review analyses the regulated activity of the CD-36 molecules in the orchestrated interplay between the mouse-induced macrophages and the graphene nanoplatelets.
Audience Take Away:
- Graphene nanoplatelets has already been rewarded by the scientific industry due to numerous benefits but the lesser facts are known about how does the macrophages are interacted with the graphene nanoplatelets and how they both react in the presence of CD-36