Title : Advances in sustainable stimuli-responsive nanoscale platforms for biomedical applications
Abstract:
The development of sustainable nanoscale platforms is revolutionizing healthcare by integrating targeted drug delivery, real-time diagnostics, and regenerative therapies, while addressing environmental challenges and promoting green transitions. This talk will highlight latest advancements in sustainable nanomaterials for biomedical applications, emphasizing multifunctionality and eco-friendly approaches.
We first explore stimuli-responsive nanocomposites for drug delivery, featuring a gold nanobipyramid (AuBiPy) core embedded in a metal-organic framework (MOF) shell [1]. Leveraging the plasmonic properties of the AuBiPy core, these systems enable controlled drug release under near-infrared (NIR) light, improving efficiency and reducing waste. Photothermal release studies demonstrated precise spatiotemporal drug delivery, combining light-responsive activation with localized therapeutic effects, minimizing off-target impacts in cancer cell models.
Additionally, electrospun nanofibers, mimicking the extracellular matrix (ECM), provide eco-friendly platforms for drug delivery and tissue engineering [2,3,4]. Zein-based nanofibers, derived from renewable corn proteins, functionalized with bioactive compounds like propolis [2] or gold nanoparticles [3], exhibited excellent biocompatibility, sustained release, and enhanced cell growth, making them ideal for wound healing and regenerative medicine. Magnetic nanoparticle-incorporated fibers further enable dual-function therapies, combining localized hyperthermia and chemotherapeutic drug delivery, activated by external magnetic fields [4].
In conclusion, these nanoscale innovations support targeted therapies, imaging, and tissue regeneration, contributing to a sustainable future in nanomedicine.
