Title : Development of continuous synthesis of iron oxide nanoparticles for biomedical and clinical applications
Abstract:
The synthesis of promising single-core iron oxide nanoparticles intended for use in biomedical applications has attracted much interest over the last decade. Several synthetic routes to achieve size, shape, crystallinity, dispersity and magnetic behavior were reported in the literature such as sol-gel synthesis, microemulsion, hydrothermal reactions, etc. Nevertheless, most of them are time-consuming and costly. Therefore, the search for a new and facile synthetic route that is simple, economical, environmentally friendly and rapid is one of the most challenging issues related to the synthesis of well-crystallized and size-controlled iron oxide nanoparticles. Herein, we report the development of a micromixer-based synthesis platform, which enables, in a very short lapse of time, the production of a large amount of stable, reproducible single-core nanoparticles with narrow size distribution and suitable surface chemistry. Moreover, the particle characteristics can be easily controlled by varying the process parameters, e.g. total flowrate, temperature and mixing ratios. The synthesis platform offers suitable magnetic carriers for specific biomedical and clinical applications.
Audience Take Away:
• Continuous synthesis saves time, cost and effort
• High product quality with scale up feasibility
• The so produced nanoparticles are important candidates for diagnostics ( Magnetic Particle Imaging) and therapy (Drug Targeting, Hyperthermia, etc.)
• Easy particle surface modification
