Nanoscience has now matured and has been transitioned from bench science to applied technology; superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in various scientific fields, not only on commercial scale but their wide use in biomedical science are more significant. Due to their tremendous behavior and applications, much effort has been invested for more than a decade, but unfortunately, successful pharmaceutical developments are still rare, despite very promising results. The main stumbling blocks are insufficiently addressed toxicity and the lack of appropriate particle stability in biological media. Even if these factors are adequately addressed, another important challenge which hampers the way to the clinic is the need to upscale the synthesis process from the milliliter lab scale to the liter scale and by doing so to meet the requirements from the regulatory authorities. At SEON we tackle exactly this issue and developed in the past a couple of iron oxide based formulations for drug targeting and contrast agents for MRI. These systems are well-designed to conform the physicochemical and toxicological requirements for their respective application. Due to a close collaboration with the Pharmacy Department of the Erlangen University Hospital, we are currently producing nanoparticles in the scaled up liter measure according to the highest possible international quality standard – the Good Manufacturing Practice (GMP) Guidlines. Based on the very promising preclinical results we are planning to bring our nanoparticle-based formulations to the clinic in the near future, if the respective funding is existing.
Audience take away:
• Iron nanoparticles can be used in medicine for diagnostics (Imaging) and therapy (Drug Targeting, Precision Medicine)
• No adverse side effects due to innovative and intelligent nanoparticle based drug delivery
• Translation into clinics using the SEON-concept becomes concrete reality if the respective funding is existing
• High scientific, medical and economic adding value