4th Edition of World Nanotechnology Conference

April 19-21, 2021 | Virtual Event

April 25 -27, 2022 | Las Vegas, United States
2019 Speakers

Jose Higino Correia

Speaker at World Nanotechnology Conference 2019 - Jose Higino Correia
University of Minho, Portugal
Title : Optogenetic neural interfaces

Abstract:

Optogenetics is a relatively new technology to achieve cell-type specific neuromodulation with millisecond-scale temporal precision. Optogenetic tools are being developed to address neuroscience challenges, and to improve knowledge of the brain networks with the ultimate aim of catalyzing new treatments for brain disorders and diseases. The accomplishment of this ambitious goal requires the implementation of mature and reliable engineered tools. In the last decade, several efforts have been made to provide full developed devices with photostimulation capability for neural tissue activation or inhibition. The success of optogenetics relies on optical tools (referred to as optrodes) which are in contact with the neural tissue. First, the design and manufacturing approaches available are reviewed, and the current challenges to accomplish appropriate multimodality, wireless optical devices are discussed. Finally, a single LED optrode with electrophysiological recording sites in a silicon probe is presented.

Audience take away:

• Overall, this presentation will be a helpful guidance to the engineering and design of optical microsystems for optogenetic applications.
• Audience related with biomedical engineering will appreciate a silicon neural probe avoiding overheating process. 
• A manufacturing methodology relies on standard microfabrication technologies: lithography, thin-film depositions and low-cost traditional mechanical blade dicing technology. 
• Fabrication results suggest a robust probe design, with 8 mm long single-shaft with a sharp tip. The 2D dicing methodology, applied to silicon wafers, facilitates the integration with patterning process, frequently used in MEMS and CMOS industry
• Low impedance values of recording sites and sufficient light power results show great potential for this design to modulate neural activity in both cortical and deeper brain regions.

Biography:

J. H. Correia graduated in Physical Engineering from University of Coimbra, Portugal in 1990. He obtained in 1999 a PhD degree at the Laboratory for Electronic Instrumentation, Delft University of Technology, The Netherlands, working in the field of microsystems for optical spectral analysis. Presently, he is a Full Professor in Department of Industrial Electronics, University of Minho, Portugal. He was the General-Chairman of Eurosensors 2003 and MME 2007, Guimaraes, Portugal. His professional interests are in micromachining and microfabrication technology for biomedical microsystems.

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