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10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2021

Adverse reactions combination therapy MDR-TB using Bedaquiline

Elena Ershova, Speaker at Nanotechnology Conferences
Khanty-Mansiysk clinical TB dispensary, Russian Federation
Title : Adverse reactions combination therapy MDR-TB using Bedaquiline


Since 2013, the Russian Federation has been using the new anti-TB drug Bedaquiline (Sirturo), whose mechanism of action is radically different from the existing anti-TB drugs. The drug has shown its high effectiveness in the treatment of drug resistant tuberculosis. In phase III clinical trials, the bedaquiline group showed a significant increase in the number of deaths without an obvious causal factor, compared with the placebo group (12.7 vs. 2.5%). Despite the high efficacy of bedaquiline, community CRAG experts expressed concerns about the safety of the drug and said that more information on the safety of Bedaquiline was urgently needed.