Title : Delivery of drugs to brain through nasal route
Abstract:
Despite the fact that the global prevalence of neurologic illnesses is increasing, most medication molecules are still unable to reach the brain in therapeutic amounts. The blood-brain barrier is made up of a thin layer of endothelial cells surrounded by astrocyte foot processes, and these anatomic features act as a considerable impediment to drug transfer from the blood to the brain. Use of the nasal route of administration to deposit medications at the olfactory region of the nares, from where they travel to the brain by methods that are still unknown, with travel via nerve fibres and transport via a perivascular pathway both being suggested. With both fluid and particle formulations, the nose-to-brain pathway has been established frequently in preclinical mice. In human trials using solution and particle formulations, the nose-to-brain pathway has also been demonstrated. With device manufacturers joining the fray, the advantages of this distribution method can be translated into approved devices. The following are the key factors that determine the efficacy of delivery via this route: delivery to the olfactory region of the nares rather than the respiratory region, a longer retention time at the nasal mucosal surface, enhanced penetration of the active through the nasal epithelia, and reduced drug metabolism in the nasal cavity.
Audience take-away:
- Audience will get to know the
- Difficulty in brain drug delivery
- Nasal drug delivery
- Application of nasal drug delivery for delivering drug to brain
