Title : Formulation and characterization of trihexyphendiyl hydro chloride loaded solid lipid nanoparticles
Abstract:
The aim of the present work was to enhance therapeutic efficacy, prevent from hepatic first pass metabolism and prevention from intestinal degradation and also overcome the drawbacks of the conventional tablet dosage form and to ensure the sustained release of Trihexyphenidyl Hydrochloride, used in the treatment of Parkinson's disease. Trihexyphenidyl loaded solid lipid nanoparticles (SLN) were prepared by double emulsion method. The mean particle size of the formulation was found to be 359.3 nm, with a zeta potential value of -9.94mV and Polydispersity index values were found to be 0.163. DSC and FTIR studies revealed change in the crystallinity index of drug when incorporated into SLN. Cell lines studies and In-vitro cytotoxicity studies was carried out to assess the safety of the formulation.
Audience take-away:
- They audience can learn about the method of preparation of trihexyphenidyl loaded solid lipid nanoparticles.
- Characterization technique’s involved in the nanoparticles loaded with drug.
- Understanding the in vitro cytotoxicity studies of the formulation using an appropriate cell lines.
