HYBRID EVENT: You can participate in person at Orlando, USA or Virtually from your home or work.

6th edition of World Nanotechnology Conference

April 24-25, 2023

April 24 -26, 2023 | Orlando, USA
World Nano 2022

Formulation and characterization of trihexyphendiyl hydro chloride loaded solid lipid nanoparticles

D Nagasamy Venkatesh, Speaker at Nanotechnology conferences
JSS College of Pharmacy, India
Title : Formulation and characterization of trihexyphendiyl hydro chloride loaded solid lipid nanoparticles


The aim of the present work was to enhance therapeutic efficacy, prevent from hepatic first pass metabolism and prevention from intestinal degradation and also overcome the drawbacks of the conventional tablet dosage form and to ensure the sustained release of Trihexyphenidyl Hydrochloride, used in the treatment of Parkinson's disease. Trihexyphenidyl loaded solid lipid nanoparticles (SLN) were prepared by double emulsion method.  The mean particle size of the formulation was found to be 359.3 nm, with a zeta potential value of -9.94mV and Polydispersity index values were found to be 0.163. DSC and FTIR studies revealed change in the crystallinity index of drug when incorporated into SLN. Cell lines studies and In-vitro cytotoxicity studies was carried out to assess the safety of the formulation.

Audience take-away:

  • They audience can learn about the method of preparation of trihexyphenidyl loaded solid lipid nanoparticles.
  • Characterization technique’s involved in the nanoparticles loaded with drug.
  • Understanding the in vitro cytotoxicity studies of the formulation using an appropriate cell lines.


Dr. D.Nagasamy Venkatesh is working as Associate Professor at Department of Pharmaceutics, JSS College of Pharmacy, Udhagamandalam. India.  Dr. D.Nagasamy Venkatesh is interested in developing certain nanobased drug delivery systems for antiviral and anticancer drugs. His research is also extended in developing oral sustained/controlled drug delivery systems for certain drugs of therapeutic interest and analytical and bio-analytical method development for such drugs. He serves as a reviewer of more than 25 peer reviewed journals including AAPS, Carbohydrate polymer, Indian Journal of Pharmaceutical Sciences. He has authored more than 50 peer-reviewed publications. He has received three best awards for his presentations/publications in national and international level conferences.