Title : Self-emulsification systems – A nanotranforming of poor aqueous solubility towards enhanced bioavailaility of drugs
Abstract:
High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. 60-70% of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. Oral route has been the major route of drug delivery for the chronic treatment of many diseases as it offers a high degree of patient compliance. Nearly 40% of new drug candidate exhibit low solubility in water. This is a challenge in development of optimum oral solid dosage form in terms of formulation design and bioavailability of new pharmaceutical products, this hampers their oral absorption and further leads to their poor bioavailability. Various researches are in progress to overcome these limitations. Novel Technologies like nano-carrier systems have become popular for improving the solubility of drugs. Lipid based formulations, among nano systems, are taking pace for the enhancement of solubility, oral absorption and hence the bioavailability of drugs. Among the lipid formulations, Self-emulsification systems are gaining popularity by offering various advantages to delivery systems. Self-emulsifying drug delivery systems are isotropic blends of oil and surfactant/co-surfactants, which, upon gentle agitation on watery media shape o/w emulsion.
Audience take-away:
- Inspite of many works published in SEDDS, the major concerns of this presentation is to discuss about the various approaches to formulate a good lipid based carrier system for poorly aqueous soluble drugs, role of various polymers and their categories used in the formulation along-with the modern technologies used for enhancing the stability of liquid SEDDS.
