Title : Synthesis, characterization, and biological screening of conducting copolymers and their nanocomposites
The recent study deals with the chemical oxidative polymerization of pyrrole and methyl anthranilate, Ppy-MA, in different molar ratios in high yields. The polymerization occurs in the presence of H2O2 and FeSO4. Subsequently, electrically conducting nanocomposites Ppy-MA/TiO2 were obtained by in situ chemical oxidative polymerization using TiO2 nanoparticles in different molar ratios. The structure and morphology of black powdered copolymers, Ppy-MA, and their nanocomposites, Ppy-MA/TiO2, were elucidated using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, transmission electron microscopy, X-ray differential, thermogravimetric analysis, and differential thermal analysis. These studies have shown that the nanocomposites, Ppy-MA/ TiO2, are thermally more stable, good electrical conductors as compared with their copolymers Ppy-MA. The copolymers Ppy-MA prepared from different monomer ratios and its nanocomposites Ppy-MA/TiO2 have been screened for their possible in vitro antibacterial activity against Staphylococcus aureus (ATCC 29213), Streptococcus mutans (ATCC 25175), Streptococcus pyogenes (MTCC 435), Staphylococcus epidermidis (MTCC 435), Bacillus cereus (MTCC 430), Corynebacterium xerosis (ATCC 373), Acetobacter bovis (Clinical isolate), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (MTCC 109), Proteus vulgaris (MTCC 426), and Pseudomonas aeruginosa (MTCC 424) using ciprofloxacin and gentamicin as standard drugs.
- The audience will have an overview on the synthetic procedures, characterization methodologies used for the synthesis of copolymers and their Nano composites.
- The audience will have an understanding about the biological applications of Nano composites as antimicrobial candidate.
- As per the findings, the Nano composites are antimicrobial in nature; therefore it is obvious that the recent study can be carried out further by other scientist, such as in vivo screening, formulation of a drug or some other biological studies.
- This research can also be used by other faculty to expand their research using the similar procedure for other reactants or copolymers or similar approach to other parameters as well as can be used for updating the knowledge on the recent approaches for teaching.