HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2023

Sungwook Jung

Sungwook Jung, Speaker at Nanotechnology Conferences
Harvard Medical School, United States
Title : Ectopic high endothelial venule-targeted nano delivery for type 1 diabetes


Targeted drug delivery systems hold the remarkable potential to improve the therapeutic index of diabetes medications. Herein, we developed a targeted delivery platform for type 1 diabetes (T1D) treatment using high endothelial venule (HEV)-targeted nanoparticles. We encapsulated anti-CD3 in PLGA nanoparticles (NPs) and conjugated mAb on the surface of NPs. Our mAb-NP localized to pancreatic lymph nodes (PLNs) and pancreata in NOD mice and encapsulation of anti-CD3 in MECA79-NP enhanced its delivery to these organs. Treatment of hyperglycermic NOD mouse model with mAb-anti-CD3-NP resulted in significant reversal of T1D, as compared to non-treatment, empty NP, and free anti-CD3. mAb-anti-CD3-NP treatment caused a marked increase of regulatory T (Treg) cells in pancreata. Our data suggested that ectopic HEV expressed in pancreata of T1D patients. Our study demonstrates that HEV-targeting nanovehicles constitute a novel drug delivery platform that can augment the effects of immunosuprression as well as reduce the inflammatory risk in treating T1D. Moreover, HEV-targeting therapeutics may be used as means by which drugs are delivered specifically to PLNs and pancreata, thereby prolonging the reversal of T1D patients.


Sungwook Jung studied Nano Chemistry at the Pohang University of Science and Technology, Republic of Korea and graduated as Ph.D. in 2015. He then joined the research group of Prof. Xiaoyuan Chen at the National Institutes of Health, Bethesda, MD, USA. After two year postdoctoral fellowship, he moved to Laboratory of Prof. Reza Abdi at Brigham and Women’s Hospital of Harvard Medical School, Boston, MA, USA. He has published more than 20 research articles in SCI(E) journals.