HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2023

Xiao Hong Nancy Xu

Xiao Hong Nancy Xu, Speaker at Nanomaterials Conference
Old Dominion University, United States
Title : New nano biotechnology for real-time imaging of single live cells


Single cells are building blocks of all living organisms.  Understanding of functions of individual live cells and their communications is essential to rationally design effective diagnosis and therapy. New tools for detecting and targeting specific individual cells would revolutionize disease diagnosis and treatments.  Current tools are unable to real-time study and control molecular machineries of single live cells with adequate quantitation, spatial and temporal resolutions and over an extended period of time. We have pioneered the development of a set of powerful new nanobiotechnologies, including photostable single plasmonic nanoparticle imaging probes, single molecular assays, single molecule nanoparticle optical biosensors (SMNOBS), and far-field photostable optical nanoscopy (PHOTON). We have demonstrated that these new tools can overcome the drawbacks of fluorescence-based imaging platforms for dynamic, single molecule and multiplexing imaging of single live cells with superior temporal and spatial resolutions and over a desired extended period of time (hours, days, weeks).  We have used these new tools to real-time study: (i) molecular cascades of signaling transduction pathways of single live cells, (ii) molecular mechanisms of multidrug resistance of single live cells, (iii) efficacies of individual drug nanocarriers, and (iv) native environments of developing embryos.  In this keynote presentation, I will describe these new nanobiotechnologies and their innovative biomedical applications.  The work has been supported by NIH and NSF.


X. Nancy Xu is an elected AAAS Fellow and Professor of Biomedical Engineering, Biomedical Sciences, Biochemistry, and Chemistry at Old Dominion University. She has pioneered the development of a set of powerful new nano biophotonics tools for biomedical applications, and has consistently published her work in high impact peer-reviewed journals.  Dr. Xu is especially well recognized for her pioneering work in single nanoparticle optics, nano optical biosensors, single molecule detection, and single live cell imaging and has received several prestigious national awards, including Nano50 Innovator Award and Nano50 Technology Award, Finalist of NIH Follow That Cell Challenge, ACS Roland F. Hirsch Award, and AAAS Mentor Award. Her profile is at www.odu.edu/~xhxu.