Title : Nanocarriers for the delivery of quercetin to inhibit the UV-induced aggregation of ?D-crystallin
Abstract:
Due to gradual environmental changes like ozone layer depletion and global warming, human eyes get exposed to UV light. Exposure to UV light can be a cause of cataract, one of the ocular diseases which may cause vision impairment. To date, lens replacement is the only treatment available for cataract. In our present study, we have carried out an extensive examination of polyphenols as inhibitors for UV-induced aggregation of γD-crystallin. On exposure to UV-C light, γD-crystallin forms fibrils instead of amorphous aggregates. Various polyphenols were tested as inhibitors, out of them quercetin, baicalein, and caffeic acid were found to be effective. As polyphenols are insoluble in water, nanoencapsulation was tried to enhance their bioavailability. CS-TPP and CS-PLGA encapsulating systems were considered as they form biodegradable nano-capsules. Out of three polyphenols (quercetin, baicalein, and caffeic acid), quercetin forms nanocarriers of smaller sizes, a must for crossing retinal barrier. Quercetin nanocarriers were considered as an effective system that could be used for therapeutic application. For these nanocarriers, encapsulation efficiency, and polyphenol release kinetics were studied. CS-PLGA NPs were found to have better loading efficiency for quercetin than CS-TPP NPs.
Audeince Take Away:
- Thank you for providing me platform to show my research. Through my presentation in form of poster I will able to share potential nanocarriers which could inhibit aggregation of γD-crystallin (aggregation of γD-crystallin is cause of cataracts)
- These nanocarriers are perfect solution to cataracts. As only solution of cataracts is lens replacement which is not possible in many developing countries
- Biodegradable nanocarriers are perfect solution to for drug delivery
