HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2024

Ncediwe Tsolekile

Ncediwe Tsolekile, Speaker at Nanotechnology Conferences
Cape Peninsula University of Technology, South Africa
Title : Novel synthesis of quaternary Zn-Cu-In-S/ZnS QDs-m THPP porphyrin conjugate for photodynamic therapy and antibacterial activities


Photodynamic Therapy (PDT) is a non-invasive therapeutic approach that eliminates improperly developing cells and bacteria. Porphyrins are utilized in PDT as photosensitizers; nonetheless, their clinical applicability has been restricted due to their poor dispersity, which causes aggregation and low yields of reactive oxygen species. We present here the conjugation of (Zn)CuInS/ZnS quantum dots (QDs) to 5,10,15,20-tetrakis(3 hydroxyphenyl)porphyrin (mTHPP) to overcome these restrictions and boost PDT efficacy. The best circumstances for QDs-porphyrin conjugation production were thoroughly investigated. The bactericidal and PDT effectiveness of the produced (Zn)CuInS/ZnS - mTHPP conjugates were also evaluated in this study. The PDT effectiveness of mTHPP, QDs, and conjugate against the murine metastatic melanoma (B16 F10 Nex2) cell line was investigated with and without LED illumination. The conjugate had the greatest loss in cell viability after LED irradiation (72%) compared to the mTHPP (1%) and bare QDs (19%). Antimicrobial experiments on Escherichia coli (E. coli) revealed that the conjugation had a greater antibacterial impact than bare QDs, even in the absence of light. According to the findings, conjugate is a potential class of materials for anti-cancer and antibacterial PDT.

Audience take Away:

  • Enhanced efficacy in Photodynamic Therapy (PDT) thus improving treatment outcomes in cancer and bacterial infections 
  • Simplification and optimization of PDT protocols
  • Potential for reducing side effects and increasing patient comfort
  • Expansion of knowledge in the fields of nanomedicine and antimicrobial treatments
  • Basis for further research and development in related areas
  • Integration into medical education and training programs


Dr. N Tsolekile earned her PhD in Chemistry from the University of Johannesburg, South Africa in 2020. She began her scientific career as a Scientist at the South African Medical Research Council. She joined Cape Peninsula University of Technology in 2014 as a Senior Lecturer and co-founded the Bio-Nanotech and Electrochemistry Research group. Her research area of interest is in the application of nanomaterials in theragnostics. She has published more than 25 research articles in international journals and has presented her work at both national and international conferences.