HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2024

Pentacyclic triterpenoid nano formulations as bioavailable drug delivery agents at cellular level

Carmen Socaciu, Speaker at Nanomaterials Conference
BIODIATECH- Proplanta SRL, Romania
Title : Pentacyclic triterpenoid nano formulations as bioavailable drug delivery agents at cellular level

Abstract:

The last decade an increasing scientific interest was focused on pentacyclic triterpenoids (betulin, betulinic acid and lupane), considering their antitumor effects without so many secondary adverse actions comparative to other synthetic anticarcinogens (e.g. Doxorubicin). Considering that pentacyclic terpenoids have a low bioavailability, new nano formulations can overcome this challenge. Our aim was to find best solvents for these molecules and to obtain nano formulations (liposomes, nano lipid particles, selfassembled structures) from a standardized extract of Betula pendula bark, in order to build bioavailable agents for targeted delivery to normal vs tumour cells (e.g. Walker 256 cells). The nano formulations obtained were characterized by size DLS measurements, UV-VIS spectrometry, fluorescence microscopy and high-performance liquid chromatography coupled with mass spectrometry (LC_MS) and compared with similar formulations containing Doxorubicin.  Comparatively, the viability tests and the apoptotic effects demonstrated that nano formulated triterpenoids can reach increased bioavailability and similar antitumor effects as Doxorubicin, but with less toxicity on normal cells.rubicin.  Comparatively, the viability tests and the apoptotic effects demonstrated that nano formulated triterpenoids can reach increased bioavailability and similar antitumor effects as Doxorubicin, but with less toxicity on normal cells. 

Audience Take Away:

  • Knowledge about pentacyclic terpenoids and their natural sources, as well the recent data related to their impact on health and disease
  • To see new innovative ways to make nanoformulations for future applicxations
  • New ways to make these valuable compounds to be used, as nano formulations in vitro and in vivo, as anticancer agents

Biography:

Dr. Carmen SOCACIU studied Chemistry at the Bbabes-Bolyai University, Cluj-Napoca, Romania and graduated as MS in 1977. She received her PhD degree in 1986 at the same institution. She got different postdoctoral grants at the University Bordeaux-France, University of Bern-Switzerland, University of Bremen-Germany. She was acting as full professor at the Department of Biochemistry at the Unoversity off Agricultural Sciences and Veterinary Medicine in Cluj-Napoca for more than 2 years and now she is the Director of the Proplanta Research Centre for Applied She has published more than 300 research articles in ISI journals ( Hirsch index 38).  

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