The presentation will be focused on exploring mathematical models which are suitable to describe cargo-delivery using nanomaterials (NMs) while assessing information from in vitro assays. Presently, less than about 0.5% of the accumulated world’s reports involving in vitro assays include a mathematical model, but this fraction is growing up steeply worldwide in recent years, signaling the recent trend in handling the biological data in a more comprehensive way. The starting mathematical model for in vitro assays is the Hill equation, herein described as a Hill-inspired approach, characterized by its Hill coefficient. In this case, the morphological parameters of the NMs are included into the original Hill coefficient, which is interpreted as the number of ligand sites in the MNM’s surface which are available for binding to receptors onto the cell membrane.
Audience Take Away:
- Those producing and handling data from bioassays would be able to incorporate a more comprehensive analysis of the data
- The produced documents (reports, patents, papers) will incorporate a cutting edge approach, thus improving the technical and scientific standards
- The efficiency and technical quality of previsions will be enhanced
Paulo C. DE MORAIS, PhD, was full Professor of Physics at the University of Brasilia (UnB) – Brazil up to 2013, Appointed as UnB’s Emeritus Professor (2014), Appointed as Guest Professor of Huazhong University of Science and Technology – China (2011), Visiting Professor at Huazhong University of Science and Technology (HUST) – China (2012-2015), Appointed as Distinguished Professor at Anhui University (AHU) – China (2016-2019), Appointed as Full Professor at Catholic University of Brasília (UCB) – Brazil (2018), Appointed as CNPq-1A Research Fellowship since 2010, 2007 Master Research Prize from UnB, 2008-member of the European ERA NET Nanoscience Committee, Member of the IEEE-Magnetic Society Technical Committee, Senior Member of the IEEE Society, 2012 China’s 1000 Foreign Expert Recipient, and 2012 Academic Excellence Award from Brazilian Professor’s Union. He held two-years (1987-1988) post-doc position with Bell Communications Research – New Jersey, USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais – Brazil. He graduated in both Chemistry (1976) and Physics (1977) at UnB. Professor Morais is member of the Brazilian Physical Society and the Institute of Electrical and Electronics Engineers – IEEE. He has served as referee for more than 50 technical journals, takes part of the Editorial Board of more than 15 technical journals and has conducted research on nanomaterials for over 40 years. He has delivered more than 150 Invited Talks all over the World. He is known for his research in preparation, characterization and applications of nanosized materials (magnetic fluid, magnetoliposome, magnetic nanoemulsion, magnetic nanocapsule, magnetic nanofilm, magnetic nanocomposite, nanosized semiconductors, polymeric dots, carbon dots, and graphene quantum dots). With nearly 500 published papers in peer reviewed journals, over 12,000 citations and 15 patents, he has appeared in recent World ranking of top 1% scientists, such as 2020-Stanford, 2022-Research.com, and 2023-AD Scientific Index.