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Title: Crushed gold shell @radioactive-iodine labeled nanoparticles as a theranostic nanoplatform for macrophage-mediated photothermal therapy

Yong Hyun Jeon

Daegu-Gyeongbuk Medical Innovation Foundation, South Korea

Biography

Yong Hyun Jeon is a senior researcherat Laboratory Animal Center in Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Korea. He also worked as a Research Assistant professor at Bio-medical Research Institute for Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease in Kyungpook National university hospital. He completed his Postdoctoral fellowship in Center for Molecular Imaging, Department of Radiology at University of Michigan,U.S.A

Abstract

Plasmonic nanostructure-mediated photothermal therapy (PTT) is a proven promising approach for cancer treatment, and new approaches for its effective delivery to tumor lesions are still being developed. This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124 labeled AuNPs with crushed gold shells (124I-Au@AuCBs) as a theranostic nanoplatform. 124I-Au@AuCBs exhibited effective photothermal conversion effects in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity. After administration of 124I-Au@AuCBs-labeled macrophages to colon tumors, intensive signals were observed at tumor lesions and in vivo PTT with laser irradiation yielded potent antitumor effects. The present results indicate the significant potential of 124I-Au@AuCBs as novel theranostics nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.

Audience take away:

• Audience will learn the radiolabeling technique with high radiochemical yield, gold shell formation, and phothermal therapy using macrophage delivery.
• It will help the audience in nanotechnology, oncology and drug discovery.