HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2022

Bashir M Jarrar

Bashir M Jarrar, Speaker at Nanomaterials Conference
Jerash university , Jordan
Title : On the toxicity of copper oxide nanoparticles


Background: Copper oxide nanomaterials (CuO NPs) have been widely utilized in many fields, including antibacterial materials, anti-tumor, osteoporosis treatment, imaging, drug delivery, cosmetics, lubricants for metallic coating, food industry, and electronics with probable potential risk to human health and the ecosystems.

Objectives: The present work was conducted to investigate the toxicity of CuO NPs in the vital organs. Methods: Adult healthy male Wister Albino rats were exposed to 36 intraperitoneal (ip) injections of CuO NPs (2 mg/kg bw). All rats were subjected to morphometric, biochemical, haematological, behavioural, histological, histochemical and transmission electron microscopy (TEM) and examinations.

Results: Chronic exposure to CuO NPs induced morphometric alterations mainly body weigh reduction and organ indices, back arching, Urinary bladder ballooning, lung abscess and renal calculi formation.

The renal tissues of rats exposed to chronic CuO NPs demonstrated proximal renal tubules degeneration, glomerular atrophy and hypercellularity, interstitial edema, renal blood vessels dilatation and congestion, occasional fibrosis and hyaline casts precipitation. In addition, chronic subjection to CuO NPs induced mitochondrial swelling and crystolysis, hydropic degeneration, lysosomal hypertrophy, apoptotic activity, nuclear deformity, chromatin dissolution and nucleoli enlargement. Moreover, erosion and disorganization of the apical microvilli, basement membrane thickening and crystals precipitation the glomerular capillary were also detected.

On the other hand, the hepatic tissue of rats exposed to nano copper oxide exhibited hepatocytes injury, Kupffer cells hyperplasia, sinusoidal alterations and inflammatory cells inflammation. Moreover, the injured hepatocytes showed mitochondrial swelling, cristolysis and matrix lysis, formation of phagocytized bodies and myelin multilayer figures, lysosomal hyperplasia, cytoplasmic degeneration and vacuolation, and hepatocytes nuclear alteration. The findings indicate that copper oxide nanoparticles interact with the hepatic tissue components and could induce alterations in the liver with the mitochondria as the main target organelles to the toxicity of copper nanomaterials. More work is recommended for better understanding the pathogenesis of copper oxide nanoparticles and nano products.

Conclusion: The findings indicate that CuO NPs interact with the tissue components and the macromolecules of the vital organs and could induce alterations may affect the functions of these vital organs. More work is recommended for better understanding the pathogenesis of nanoparticles in general and copper oxide nanomaterials in specific.

Audience take-away:

  • The morphometric, histological, histochemical and ultrastructural alterations that might be induced by chronic exposure to copper oxide nanoparticle.
  • The effects of copper nanomaterial in the vital organs of the body.
  • Application and potential risks of copper nano materials.


Bashir Jarrar is a professor of histocytotechnology at Jerash University, Jordan. He received his PhD in 1999 and by then Joined King Saud University and and after Jouf University, Saudi Arabia as a senior researcher. Prof Jarrar is an author of 37 books and published 101 research articles in ISI Journals. He used the tools of histocytotechnology to answer some questions on the toxicity of pollutants, drugs and nanomaterials.