HYBRID EVENT: You can participate in person at Rome, Italy or Virtually from your home or work.

10th Edition of World Nanotechnology Conference

March 10-12, 2025

March 10 -12, 2025 | Rome, Italy
World Nano 2024

Antonio Vassallo

Antonio Vassallo, Speaker at Nanomaterials Conference
University of Basilicata, Italy
Title : Nanotransporters for the release of bioactive molecules


In this study, the nanoformulation of plant extracts in phospholipid vesicles was performed to improve phytochemicals’ applicability in potential skin products. In recent years, the scientific community and pharmaceutical and cosmetic industries gave much attention to plant-derived products with active ingredients. The antioxidant, antibacterial, wound healing, anti-aging, sun protection, and antiinflammatory activities are some of their properties highlighted for topical application. Despite this, plant compounds present some drawbacks related to their poor solubility, instability, reduced skin permeation, and low skin retention time, which strongly restrict their topical application. Nanotechnology emerges as an innovative strategy to tackle these limitations: by manipulating materials and reducing their size at the nanometer scale, new structures able to incorporate different active molecules are produced. Nanocarrier-based delivery preserves biomolecules from degradation and increases their bioavailability, at the same time. In this research, the plant material was obtained through alcoholic extractions of different parts of some common plants. Their incorporation in phospholipid vesicles was carried out by a simple sonication of extracts and phospholipids in dispersant solutions. To verify that the nanoformulations had optimal features for skin delivery, a deep characterization was performed, in terms of size, surface charge, sample homogeneity, shape, degree of lamellarity, and entrapment efficiency of the main compounds characteristic of each extract. Their biocompatibility was assayed with different skin cell lines as well as their antioxidant potential. Our results suggest that phospholipid vesicles incorporating plant extracts could be good candidates for topical delivery.

Audience Take Away:

  • Taking advantage of the nano-sized structures, nanocarriers help poorly soluble molecules to become more bioavailable and protect them from degradation
  • The modifiable surfaces of nanocarriers extend their usability in different biomedical applications, especially in targeted therapy: their modification not only stabilizes but also functionalizes them to be responsive to different stimuli
  • Liposomes have attractive biological properties, including biocompatibility, biodegradability, low toxicity, small size, and different cargo transportability, that increase their application area from drug and gene delivery to the diagnostic sector, and cosmetics, food, and chemical industries


Prof. ANTONIO VASSALLO graduated as MS on Pharmacy in 2002 at the Salerno University, Italy, in 2005 he obtained his Specialization in Hospital Pharmacy. He received his PhD degree in 2010 at the same institution. In 2010 he won a position as Assistant Professor at the University of Basilicata, Italy and now he works in the Pharmaceutical and technological application division at University of Basilicata, from 2022 Associate Professor. Research objectives: Studies of formulation, preparation and control of synthetic or biologically active compounds in conventional and innovative dosage forms. He has published more than 70 research articles in SCI(E) journals.