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Title: Functionalization of iron oxide-based magnetic nanoparticles with gold shells

Agne Mikalauskaite

Institute Center for Physical Sciences and State research Technology, Lithuania

Biography

Agnė Mikalauskaitė graduated from the Master of Science in Nanomaterial Chemistry and started Ph.D. in Chemistry.

During this period, the results of the Master's studies and doctoral studies were summarized and published in 5 scientific publications in Web-of-sci magazines with a citation index. Average index of quoted articles> 2.0. Also, the results of the last 3 years of research work have been presented at 9 international conferences, of which 5 oral in France, Germany, Lithuania and 4 stands in Lithuania. Scientific qualification upgrading in international schools related to the doctoral program: Portugal, VII Hands-on Course in Sample Preparation Using Nanoparticles for Proteomics. June 27-29, 2017 (4 days), BASF Summer School in Germany, 133rd International Summer Course August 21-26, 2017 Duration (week) and 1 month internship in Italy, Modena, Modena University of Reggio Emilia, Faculty of Physics and Nanosciences, Prof. The Marco Affronte Laboratory, which has been trained to characterize the objects of research, equipment for the detection of highly qualified magnetic properties.

Abstract

Among various functional nanostructures, gold coated and decorated magnetic nanoparticles (Nps) have inspired huge attention because of biological compatibility and recent potential applications in nanomedicine, bio-sensing, drug delivery, cells separation, etc. In fact, surface coating of superparamagnetic Nps with biocompatible polymeric, organic or precious metal shell is a familiar tool to tune the interactions between Nps, their saturation magnetization, surface energy and properties.
Functionalized superparamagnetic nanoparticles (Nps) recently are one of the most investigated research topics. In this study, we present an efficient protocol for gold deposition onto the surface of cobalt ferrite (CoFe2O4) Nps by a simple one-pot reduction of AuCl4- ions with methionine amino acid, that in turn produce the biocompatible Nps stabilizing shell. In contrast to reported gold deposition recipes, the adopted herein is distinguished by the simplicity and evade of mono-gold crystallites nucleation and growth in the deposition solution bulk. This work was based on our observation that in contrast to other amino acids amino acid methionine is prone to reduce AuCl4- species at the walls of glass vessel instead of nucleation the Au0 particles in the solution bulk. In the presence of CoFe2O4 Nps, however, the covering of magnetic Nps instead of glass vessel walls was observed. The advantage of our functionalization method lies in its high yield, simplicity and avoidance of gold crystals formation.
The innovative gold deposition method is expected open new horizons for the design of biocompatible water dispersible gold/methionine-functionalized ferrite nanoparticles by a simply controllable way.

Audience take away:

• Three different synthesis methods for gold deposition on magnetic nanoparticles shells, as well as their different application for nanomedicine diagnostic, detection and delivery.
• First after this presentation the audience will know magnetic nanoparticle synthesis aspects to be avoided during hydrothermal synthesis, recommendations as best done. Also general information will be presented for other skills scientist. General, specific/concise information on the functionalization of magnetic nanoparticles.