Combating CoV infections is a massive concern for healthcare systems, owing to the virus's high transmission rate and ability to withstand several mutations. The use of nanotechnology in the diagnosis, treatment, and prevention of COVID-19 has enormous potential. Several nano-based formulations have been demonstrated to increase antiviral medication target delivery and therapeutic efficacy. A new generation of vaccines based on various types of nanomaterials, with better antigen stability, target delivery, and controlled-release, is another promising alternative. The development of technologies for speedy, accurate, and sensitive diagnosis, the manufacturing of effective disinfectants, the delivery of mRNA vaccines into human cells, and the delivery of antiviral medicines into the body are all nanotechnology-based solutions for COVID-19 disease management.