A viral infectious disease emerged at the end of 2019, and it rapidly spread over the globe. The pandemic's global impact is scary, and it may not have reached its apex yet. The human race is likewise in a state of crisis as a result of mandatory quarantines and lockdowns. Nanoparticles (NPs) and viruses have similar scales of activity, making nanotechnology a powerful tool for vaccine development and immunoengineering. Researchers in the field of nanomedicine have been constantly investigating the relationship between the ability of various nano systems and viral vectors to deliver genes and high infectivity. Nanotechnology could be the safest alternative to novel vaccine development technologies since NPs can replicate the structural and functional properties of viruses. Two nanoparticle-based vaccinations on the verge of being approved by the US Food and Drug Administration could be a game-changer in the fight against the COVID-19 pandemic. If they succeed, they will contribute to the mitigation of a global health catastrophe of unprecedented dimensions in modern history, illustrating the worldwide effect of nanomedicine and spreading awareness about its potential advantages to the broadest possible audience.