Dar-Bin Shieh studied Dentistry at the National Yang-Ming University, Taiwan and graduated as DDS in 1988. He then joined the research group of Prof. David Kwiatkowski at the department of experimental medicine at Harvard Medical School and in 1991 after finished his clinical training in Taiwan. He received his PhD degree in 1996 from Harvard School of Dental Medicine and served as a research fellow in Brigham and Women’s Hospital. After two years fellowship, he obtained the position of an Assistant Professor at the National Cheng Kung University and also join appointed as a session chief in the department of stomatology in NCKU Hospital. In 2018, he was recruited serve as the Deputy Minister of Ministry of Science and Technology in Taiwan and retired after 3 years of service. He was appointed as chair professor in National Cheng Kung University in 2021 and has published more than 130 research articles in SCI(E) journals.