Title : Super paramagnetic iron oxide nanoparticles (SPIONs) for biomedicine applications
In recent years, iron oxide nanoparticles have attracted a great deal of interesting due to their unique magnetic, electric, optic, and catalytic properties. Therefore, iron oxides nanoparticles have been widely used in many potential applications. In biomedicine application both maghemite and magnetite are most suitable due to their biocompatible and non-toxic to human. Recently, superparamagnetic iron oxide nanoparticles (SPIONs) have high importance in the biotechnology industry. In particular, iron oxide nanoparticles in both form Fe3O4 and Fe2O3 at the particle diameter about 20 nm or 15 nm. Thus, superparamagnetic iron oxide nanoparticles are extensively used in many fields of biomedical applications such as cancer treatment, tissue repair, cell labeling. In addition, SPIONs is considered as one of the most interesting applications of a magnetic resonance imaging (MRI) contrast agent for cancer diagnosis and potentially used in drug delivery . Iron oxide nanoparticle with a positive charge are most suitable and better internalized by human breast cancer cells than those IONPs with negative charge. SPIONs has very strongly response to a magnetic field which enhance and improve the resolution of the image. Thus, better pictures SPIONs can be obtained that enable to reach the target tumor site through active targeting, passive targeting and magnetic targeting by applying an external magnetic field . Moreover, SPIONs can be considered as a very promising agent for hyperthermia therapy by the heating cells in the temperature between 41 to 47°C which causes the death of tumor cells. Therefore, (SPIONs) gain considerable interesting for cancer treatment and successfully used to assist with the diagnosis of cancers of the liver and spleen.