2nd Edition of World Nanotechnology Conference

April 27-29, 2020 | Baltimore, USA

Crowne Plaza Hotel Baltimore Dowtown –
Inner Harbor, 105 W Fayette Street
Baltimore, MD 21201 USA
Phone : 1 (702) 988 2320
Toll Free: 1800–883-8082
Whatsapp: +1 (540) 709-1879
Email: worldnano@magnus-group.org
April 27-29, 2020 | Baltimore, USA

K.S.Meena

Speaker for Nanotechnology Conferences  2020
K.S.Meena
Queen Mary's College, India
Title : Xyloglucan decorated and chitosan functionalized graphene oxide mediated novel anticancer drug delivery approach

Abstract:

The present study focuses on the development of a novel xyloglucan(XG) –decorated and chitosan functionalized graphene oxide mediated drug delivery system for the delivery of Ulvan isolated from green algae Ulvan lactua(UL)  as an anticancer model drug. Chitosan-functionalized graphene oxide (GO -CS) were successfully synthesized. The functionalized nanobiocomposite were further decorated with xyloglucan. The nanobiocomposite thus synthesized  was  loaded with sulphated polysaccharides such as the so called Ulvan (Ulva lactua) from green algae used as anti cancer model drug and characterized by UV-vis Spectroscopy(UV), fourier transform infrared spectroscopy (FTIR), scanning electron microscopy(SEM), transmission Electron Microscopy (TEM), atomic force microscopy (AFM), x-ray diffractometer (XRD) , thermogravimetric analysis(TGA), raman Spectroscopy, x-ray photoelectron spectroscopy (XPS), particle size analyser and zeta potential. The loading and release of ulvan indicated strong pH dependence and imply a bonding interaction between chitosan functionalized graphene oxide and Ulvan. The biocompatibility of the nanobiocomposites was studied via hemolysis and anti-inflammatory and cellular toxicity was assayed by 3(4,5 Dimethylthiazol 2 yl) 2,5 Diphenyltetrazolium bromide (MTT) against U 937 and U87 cell lines.

Audience take away:

•    The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy so an attempt has been made to present seaweed polysaccharide as anticancer model drug owing to its properties

•    Prepared nanohybrid system offers a novel formulation that combines the unique properties of a biodegradable material, chitosan, graphene oxide and sulphated polysaccharide for biomedical application.

•    The introduction of targeting moieties to polysacharrides based nanoparticles will improve their therapeutic efficacy which also reducing side effects and has high potential to address the current challenges in drug delivery.

•    Studies on seaweed polysaccharides based nanoparticles both in vitro and in vivo as well as targeted drug release achievable by these systems, which will support their future use in clinical settings.

Biography:

Dr.K.S.Meena started learning Chemistry at undergraduate level at Women’s Christian College, Nagercoil, Tamilnadu, India. She was awarded the Post Graduation Degree (1984) from Madurai Kamaraj University, Madurai,Tamilnadu and completed her Master of Philosophy (1986) from Annamalai University, Tamilnadu, India. She got appointment as Assistant Professor in the Collegiate Education in 1987. She was awarded Ph.D (2009) by University of Madras. She joined Queen Mary’s College in 2002 and took over various positions as The Head of Department, Controller of Examinations and Co- ordinator of BIFC, QMC and was promoted as Principal in 2018. She has organized many National conferences and also presented papers in many International Conferences such as NANOSMAT –USA, May 2016 at University of Texas and 8th World Medical NANOTECHNOLOGY Congress & Expo Dallas, USA, June 2016. She has published around 40 research articles in National and International Science Journals

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